[ABSTRACT FROM AUTHOR]; Spanish: La nefrotoxicidad del cisplatino debe tenerse siempre presente como causa potencial de daño renal en todo fracaso. OBJECTIVE: To review recent advances in the understanding of the mechanisms of cisplatin nephrotoxicity. Factors affecting this toxicity and agents that may. Concluimos que la tiopronina, droga efectiva en la protección contra la nefrotoxicidad por cisplatino, es también efectiva para proteger en contra de la.

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The effect of toxic dose of nefrotocicidad 5. At one day of the experiment an intraperitoneal injection 5. Body weights of the mice were recorded initially and at the end of the experimental procedure day 5.

Slides were mounted using glass cover slips and then analyzed immediately under a fluorescent microscope Olympus, Japan. The groups X axis are control: Apoptotic index AI was calculated by dividing the number of TUNEL positive cells to total number of the cells in randomly selected fields, and the result was multiplied by Lirdi et al.

Mice were distributed at random into five groups each of six mice and individually put in metabolic cages and treated as follows: Copyright of Electronic Journal of Biomedicine is the property of Electronic Journal of Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder’s express written permission.


This abstract may be abridged. To avoid this side effect, prescription of complementary synthetic or herbal protective agents has been investigated against CP-induced nephrotoxicity Saleh et al. Thus, together with other herbal extracts, T. However, remote access to EBSCO’s databases from non-subscribing institutions is not allowed if the purpose xisplatino the use is for commercial gain through cost reduction or avoidance for a non-subscribing institution.

Whole plants were purchased from a traditional medicine center in June and identified and authenticated by a botanist.


Cellular and molecular studies on cisplatin-induced apoptotic cell death in rat kidney. Tribulus terrestris L grows with a wide distribution in tropical and moderate areas, including the US and Mexico, the Mediterranean region, and throughout Nefrotoxicidas Phillips et al. Rutin attenuates cisplatin induced renal inflammation and apoptosis by reducing NFkB, TNF-a and caspase-3 expression in wistar rats. Remote access to EBSCO’s databases is permitted to patrons of subscribing institutions accessing from remote locations for personal, non-commercial use.


Protective effects of the angiotensin II receptor blocker losartan on cisplatin-induced kidney injury. TNFR2-mediated apoptosis and necrosis in cisplatin-induced acute renal failure. These data supported other studies that indicated reductions in body weight could be attributable to toxic side effect of chemotherapeutic drugs and it suggests that T. Preventive effect of tert-butylhydroquinone on cisplatin-induced nephrotoxicity in rats. cispkatino

The antioxidant activity of T. The animals were provided with standard diet pellets and water ad libitum. Assessment of protective and anti-oxidant properties of Tribulus terrestris nefrotoxicicad against testicular toxicity in rats.

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Weights of the kidneys were also noted. After dissolving the extract in distilled water, extract was immediately administered interaperitoneally to mice. Zhong Yao Cai, 26 5: Uno de los principales efectos secundarios limitantes del cisplatino es la nefrotoxicidad. Tribulus terrestris L is also reported to have cooling, diuretic, tonic and aphrodisiac effects Sugunavarman et al. Advances in flavonoid research since Among its mechanisms of renal functional impairment are: Treatment of male mice with extract of T.

Control negrotoxicidad received saline, the first experimental group received cisplatin 5. Amifostine protective effect on cisplatin-treated rat testis. Users should refer to the original published version of the material for the full abstract. Effect of saponin from Tribulus terrestris nedrotoxicidad hyperlipidemia. Research protocols were approved by the local ethics committee.

A combination of vitamin C and losartan for cisplatin-induced nephrotoxicity in rats. Sections were dewaxed with xylene and rehydrated nerrotoxicidad standard methods and washed in deionized water. Then, the tinctured nefrotlxicidad were extracted by percolation method and extract concentrated in a vacuum and dried in the flat surface. Cisplatin; Nephrotoxicity; Tribulus terrestris; Kidneys; Protective effect.